Author

Siân Hamer

Institute of Cancer ResearchORCID 0000-0002-0235-6786Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:multiome· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Alejandra BrunaiD· 3 shared Alejandro Allo AnidoiD· 2 shared Ayeh Sadat SadriD· 2 shared Christie English· 2 shared Emilia CheniD· 2 shared Abigail SheaiD· 1 shared Alessandra QualizzaiD· 1 shared Anchel De Jaime-SogueroiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Alejandra BrunaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemotherapy-treated breast cancer cells activate the Wnt signaling pathway to enter a diapause-DTP state.

Youssef El Laithy, Willy Antoni Abreu de Oliveira, Anirudh Pabba, Alessandra Qualizza, Gwenny Cosemans, Paula García-Díaz, François Richard, Paraskevi Athanasouli, Carla Ríos‐Luci, Wout De Wispelaere, Larissa Mourão, Siân Hamer, Stijn Moens, Anchel De Jaime-Soguero, Maria Francesca Baietti, , Frederic Lluís

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

Cancer Research · Oct 21, 2025Peer-reviewedCancer Biology

AP-1 Primes Transcriptional Noise-Led Cancer Treatment Adaptation Through KDM5 Chromatin Rewiring

Alejandro Allo Anido, Cecilia Roux, Ayeh Sadat Sadr, Siân Hamer, Emilia Chen, Abigail Shea, Christie English, Charlotte Butterworth, Harvey Che, Angella Bellini, Birgit Geoerger, Gudrun Schleiermacher, Louis Chesler, Michael David Morgan, Alejandra Bruna

The paper identifies transcriptional noise as a driver of cancer treatment adaptation through AP-1 and KDM5-mediated chromatin rewiring in neuroblastoma and hepatoblastoma.

bioRxiv · Oct 13, 2025 · PreprintCancer Biology

Integrated Lineage Tracing in Hepatoblastoma Finds a Plasticity-Proliferation Axis Drives Adaptation

Emilia Chen, Christie English, Alejandro Allo Anido, Ayeh Sadat Sadr, Marc Miravet-Marti, Laura Zanatto, Andrea Michelle Castaneda Moreno, Siân Hamer, Emilie Inderise, Carolina Armengol, Pau Sancho‐Bru, Stefano Cairo, Alejandra Bruna

This study uses single-cell multiomics to trace clonal and phenotypic dynamics in hepatoblastoma after cisplatin treatment, identifying a plasticity-proliferation axis driven by BIRC5.

bioRxiv · Apr 16, 2025 · PreprintCancer Biology