HEB collaborates with TCR signaling to upregulate Id3 and enable γ δ cell maturation in the fetal thymus
Johanna S. Selvaratnam, Juliana Dutra Barbosa da Rocha, Vinothkumar Rajan, Helen H. Wang, Emily C. Reddy, Miki S. Gams, Jenny Jiahuan Liu, Cornelis Murre, David L. Wiest, Cynthia J. Guidos, Juan Carlos Zúñiga‐Pflücker, Michele Kay Anderson
The paper shows HEB and TCR signaling work together to increase Id3, which is needed for fetal γδ T cells to mature into IL-17-producing cells.
eLife · Apr 22, 2026Peer-reviewedImmunology