FUS post-transcriptional splicing is autoregulated via RNA condensation with therapeutic potential for ALS-FUS
Wan-Ping Huang, Vedanth Kumar, Karen Yap, Haiyan An, Sabin J. John, Rachel E. Hodgson, Anna Sanchez Avila, Emily Day, Brittany C. S. Ellis, Tek Hong Chung, Jenny Lord, Michaela Müller-McNicoll, Eugene V. Makeyev, Tatyana A. Shelkovnikova
This study shows that FUS RNA condensation regulates its splicing and that disrupting this process can reduce FUS levels, offering a potential therapeutic strategy for ALS-FUS.
Science Advances · Jul 23, 2025Peer-reviewedCell Biology