Eugene V. Makeyev

HCR-Proxy maps RNA-proximal proteomes at subcompartmental resolution, revealing sequence-encoded protein partitioning in nucleolar condensates.

This study shows that FUS RNA condensation regulates its splicing and that disrupting this process can reduce FUS levels, offering a potential therapeutic strategy for ALS-FUS.

This study identifies somatic mutations in cleavage and polyadenylation signals of tumour suppressor genes as a novel class of noncoding drivers in cancer.

The paper identifies SRS-lncRNAs expressed during neuronal differentiation and shows their potential to interact with RNA-binding proteins.

The paper develops an R package to analyze AS-NMD events in neuronal differentiation and finds that NS-CEs regulate gene downregulation in developing neurons.

The paper identifies an intronic enhancer region in the BDNF gene that regulates transcript-specific expression in neurons through an E-box element linked to pro-neural transcription factors.

The paper identifies altered nucleocytoplasmic partitioning and nuclear accumulation of polyadenylated transcripts as conserved features of quiescence in neural stem cells.

The paper shows that SNRNP70 in axons regulates transcript stability and splice variants, affecting motor connectivity development.

This study identifies SFPQ's role in repressing cryptic last exons, showing its conservation across species and relevance to neurodegenerative diseases.