Author

Karen Yap

King's College LondonORCID 0000-0002-0182-4795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Eugene V. MakeyeviD· 3 shared Andreas PichlmairiD· 1 shared Anja TrupejiD· 1 shared Anna Sanchez Avila· 1 shared Anna ZhuravskayaiD· 1 shared Boštjan KokotiD· 1 shared Brittany C. S. Ellis· 1 shared Emily Day· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Eugene V. MakeyevORCID

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Author profile →

3 papers

Recent·Most cited

HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution

Anja Trupej, Valter Bergant, Jona Novljan, Martin Dodel, Tajda Klobučar, Maksimiljan Adamek, Flora C. Y. Lee, Karen Yap, Eugene V. Makeyev, Boštjan Kokot, Luka Čehovin Zajc, Andreas Pichlmair, Iztok Urbančič, Faraz K. Mardakheh, Miha Modic

HCR-Proxy maps RNA-proximal proteomes at subcompartmental resolution, revealing sequence-encoded protein partitioning in nucleolar condensates.

Nucleic Acids Research · Jan 24, 2026Peer-reviewedMolecular Biology

FUS post-transcriptional splicing is autoregulated via RNA condensation with therapeutic potential for ALS-FUS

Wan-Ping Huang, Vedanth Kumar, Karen Yap, Haiyan An, Sabin J. John, Rachel E. Hodgson, Anna Sanchez Avila, Emily Day, Brittany C. S. Ellis, Tek Hong Chung, Jenny Lord, Michaela Müller-McNicoll, Eugene V. Makeyev, Tatyana A. Shelkovnikova

This study shows that FUS RNA condensation regulates its splicing and that disrupting this process can reduce FUS levels, offering a potential therapeutic strategy for ALS-FUS.

Science Advances · Jul 23, 2025Peer-reviewedCell Biology

Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing neurons

Anna Zhuravskaya, Karen Yap, Fursham Hamid, Eugene V. Makeyev

The paper develops an R package to analyze AS-NMD events in neuronal differentiation and finds that NS-CEs regulate gene downregulation in developing neurons.

bioRxiv · Sep 4, 2023 · PreprintMolecular Biology