Predicting Human Pharmacokinetic Parameters of Drugs using a Multi-Tissue Chip Platform Integrating Liver, Kidney, and Skeletal Muscle Microphysiological Systems
Jason S. Sherfey, Shiny Amala Priya Rajan, Lauren M. Nichols, Paarth Parekh, J. Tyler Smith, Lauren Gregory, Frances Clark, Eugene P. Kadar, Shivam Ohri, Billy T. George, David A. Tess, J Gosset, Jennifer L. Liras, Emily Geishecker, Ronald Scott Obach, Murat Cirit
This study develops a multi-tissue chip platform to predict human pharmacokinetic parameters of drugs without animal testing, showing accurate correlation with clinical data.
Lab on a Chip · Jan 1, 2026Peer-reviewedBioengineering