ImmunologyJournal of Clinical InvestigationPeer-reviewed
SHORT-TERM CALORIC RESTRICTION IN MICE PROMOTES RESOLUTION OF ATHEROSCLEROSIS, WHILE WEIGHT REGAIN ACCELERATES ITS PROGRESSION
Bianca Scolaro, Franziska Krautter, Emily J. Brown…·Edward A A Fisher
This study shows that short-term caloric restriction in mice reduces atherosclerosis by promoting Fcgr4+ macrophages, while weight regain accelerates plaque progression by eliminating these cells and reprogramming immune progenitors.