Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice
Gabrielle L. Sell, Wendy Xin, Emily K. Cook, Mark A. Zbinden, Thomas Schaffer, Robert N. O’Meally, Robert Norman Cole, Antonello Bonci, Seth S. Margolis
This study identifies Ephexin5 as a key UBE3A substrate whose removal rescues hippocampal dysfunction and behavioral deficits in Angelman syndrome mouse models.
Scientific Reports · Sep 30, 2021Peer-reviewedNeuroscience