Seth S. Margolis

This study identifies YAP's role in controlling cell migration and invasion via a Rho-GTPase switch, with implications for glioblastoma progression.

This paper identifies rapaprotin as a 26S proteasome assembly inhibitor that is activated by PREP to induce apoptosis and synergizes with proteasome inhibitors in cancer cells.

This study shows neuronal membrane proteasomes regulate neural activity and are essential for learning-induced behavioral plasticity in Xenopus laevis tadpoles.

This study identifies Ephexin5 as a key UBE3A substrate whose removal rescues hippocampal dysfunction and behavioral deficits in Angelman syndrome mouse models.