Robert N. O’Meally

SureQuant IS-PRM Enables Cross-Species Targeted Quantification of Retinoid Metabolism and Signaling Proteins in the Heart

The paper develops a targeted proteomics method to quantify retinoid metabolism and signaling proteins across species and tissues, revealing tissue-specific networks and developmental changes in the heart.

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways

The paper identifies HTT interactors involved in DNA damage response, chromatin remodeling, and RNA processing pathways, revealing HTT's role in double strand break repair and its interaction with DNA-PKcs and RNA binding proteins.

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression

This study investigates the effects of p38 MAPK inhibition on cardiac remodeling in a guinea pig HF model, finding that SB203580 treatment protects cardiac function and phosphoproteome integrity.

Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice

This study identifies Ephexin5 as a key UBE3A substrate whose removal rescues hippocampal dysfunction and behavioral deficits in Angelman syndrome mouse models.