BCR ligation selectively inhibits IgE class switch recombination
Adam Kevin Wade-Vallance, Zhiyong Yang, Jeremy B. Libang, Ananya Krishnapura, James B. Jung, Emily Matcham, Chung-An M. Wu, Marcus J Robinson, Christopher D.C. Allen
This study shows that BCR ligation selectively inhibits IgE class switch recombination in mouse and human B cells, with synergistic effects from IL-21 and TGFβ1.
Journal of Allergy and Clinical Immunology · Jun 10, 2026Peer-reviewedImmunology