James B. Jung

BCR ligation selectively inhibits IgE class switch recombination

This study shows that BCR ligation selectively inhibits IgE class switch recombination in mouse and human B cells, with synergistic effects from IL-21 and TGFβ1.

Time-resolved cryo-EM reveals conformational trajectory of allosteric activation in isocitrate lyase

The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.

Structural Basis for C8 methylation of 23S ribosomal RNA by Cfr

The paper determines the Cryo-EM structure of Cfr, revealing its mechanism of C8 methylation on 23S rRNA and its role in antibiotic resistance.

Synthetic Rewiring of Virus-Like Particles via Circular Permutation Enables Modular Peptide Display and Protein Encapsulation

The paper demonstrates the use of circular permutation to engineer virus-like particles, enabling peptide display and protein encapsulation through a comprehensive library and cryo-EM validation.