Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease
Yasir H. Qureshi, Jia Guo, John H Rinald, Zongyu Li, Rajesh Kumar Soni, Ananya Govindarajan, Emily Tortora, Genoveva Uzunova, Yanting Yang, Suvarnambiga Kannan, Priyanka Nanayakkara, Carol M. Troy, Scott A. Small
This study shows that disrupting SORL1-retromer recycling in mice leads to age-dependent brain atrophy resembling Alzheimer's disease, which can be reversed by restoring SORL1 function.
bioRxiv · Oct 31, 2026 · PreprintNeuroscience