Author

Suvarnambiga Kannan

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Scott A. SmalliD· 4 shared Yasir H. QureshiiD· 4 shared Gregory A. PetskoiD· 3 shared Ananya Govindarajan· 2 shared Samuel D. Waksal· 2 shared Vivek M. PateliD· 2 shared Akira SawaiD· 1 shared Atsushi SaitoiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Scott A. SmallORCID

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5 papers

Recent·Most cited

Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease

Yasir H. Qureshi, Jia Guo, John H Rinald, Zongyu Li, Rajesh Kumar Soni, Ananya Govindarajan, Emily Tortora, Genoveva Uzunova, Yanting Yang, Suvarnambiga Kannan, Priyanka Nanayakkara, Carol M. Troy, Scott A. Small

This study shows that disrupting SORL1-retromer recycling in mice leads to age-dependent brain atrophy resembling Alzheimer's disease, which can be reversed by restoring SORL1 function.

bioRxiv · Oct 31, 2026 · PreprintNeuroscience

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer's disease

Yasir H. Qureshi, Charles A. Williams, István Hajdú, Suvarnambiga Kannan, Ananya Govindarajan, Barbara M. Végh, Gregory A. Petsko, Jessica E. Young, Péter Závodszky, Scott A. Small

Pharmacological inhibition of RhoGEF12 increases endosomal SORL1-retromer recycling and reduces pathogenic amyloid secretion in human neuronal models, identifying a novel, targetable pathway for treating Alzheimer's disease.

bioRxiv · Mar 9, 2026 · PreprintNeuroscience

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

Ho Namkung, Hiroshi Yukitake, Daisuke Fukudome, Brian J. Lee, Mengnan Tian, Gianluca Ursini, Atsushi Saito, Shravika Lam, Suvarnambiga Kannan, Rupali Srivastava, Minae Niwa, Kamal Sharma, Peter P. Zandi, Hanna Jaaro-Peled, Koko Ishizuka, , Akira Sawa

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

Neuron · Nov 14, 2022Peer-reviewedNeuroscience

Retromer Combinatorials for Gene-Therapy Across a Spectrum of Neurological Diseases

Yasir H. Qureshi, Vivek M. Patel, Suvarnambiga Kannan, Samuel D. Waksal, Gregory A. Petsko, Scott A. Small

The paper tests combinatorial gene therapy for retromer-related neurological diseases by expressing VPS35 with VPS26 paralogs in neurons, showing synergistic effects on retromer function and Sorl1 levels.

bioRxiv · Sep 3, 2020 · PreprintNeuroscience

Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus

Yasir H. Qureshi, Diego E. Berman, Ronald L. Klein, Vivek M. Patel, Sabrina Simoes, Suvarnambiga Kannan, Rebecca L. Cox, Samuel D. Waksal, Beth Stevens, Gregory A. Petsko, Scott A. Small

This study shows that restoring VPS35 in the hippocampus of mice with chronic neuronal VPS35 depletion rescues APP cleavage and glutamate receptor levels, and reduces glial activation similar to Alzheimer's disease.

Alzheimer s & Dementia · Jul 1, 2019Peer-reviewedNeuroscience