The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression
Sebastian Herdan, Katharina Kohm, Robert Warneke, Florian Roth, Nadja Glaser, Lucia Villani, Nele Rüping, Lea Dreher, Nicolas Görge, Trung Duc Hoang, Emina Schunke, Claudia C. Häse, Juri Rappsilber, Günter Fritz, Fabian M. Commichau, , Julia Steuber
This study identifies PepA as a regulator of nhaB gene expression in Vibrio cholerae, revealing its role in Na+ homeostasis through suppressor mutations in a nhaA nqr mutant.
Journal of Bacteriology · Jul 30, 2026Peer-reviewedMicrobiology