Daily HIV pre-exposure prophylaxis enhances monocyte activation and effector function and reprogrammes cellular metabolism.
Gráinne Jameson, Dearbhla M Murphy, Isabella Batten, Sarah A. Connolly, Adam H. Dyer, Annmarie White, Sarah Cochrane, Laura L. Quinn, Emma J. Devitt, Giovanni Carlo Federico Villa, Sharee A. Basdeo, Liam Townsend
This study shows daily HIV PrEP with TDF/FTC increases monocyte activation, enhances pro-inflammatory responses, and reprograms immune cell metabolism in HIV-negative individuals.
bioRxiv · Jan 9, 2026 · PreprintImmunology