Sharee A. Basdeo

This study shows HIV-1 infection suppresses Mtb-induced glycolytic reprogramming in macrophages, altering immunometabolic responses and increasing TB susceptibility.

This study compares monocyte phenotypes, function, and metabolism in latent TB infection, active TB disease, and healthy controls, finding distinct metabolic and cytokine profiles that differentiate the conditions.

This study shows daily HIV PrEP with TDF/FTC increases monocyte activation, enhances pro-inflammatory responses, and reprograms immune cell metabolism in HIV-negative individuals.

This study shows dexamethasone reduces glycolysis in human macrophages but enhances mycobacterial killing, suggesting a potential therapeutic benefit in tuberculosis.

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.