Aggregation of misfolded proteins in the sperm head impairs preimplantation embryo development
E Anta, Froylan Sosa, Jéssica Nora Drum, Kelsey Lockhart, Katy S Stoecklein, Lindsey Fallon, Emma Keller, Alexandra Keller, Karl C. Kerns, M. Sofia Ortega
This study shows that high levels of misfolded protein aggregates in bovine sperm impair preimplantation embryo development, affecting blastocyst formation and increasing developmental arrest.
bioRxiv · Jun 4, 2026 · PreprintCell Biology