Martha Sofia Ortega

This study shows that high levels of misfolded protein aggregates in bovine sperm impair preimplantation embryo development, affecting blastocyst formation and increasing developmental arrest.

This study investigates the impact of uterine disease on oocyte developmental capacity in dairy cows, finding reduced cleavage rates in oocytes collected at 1 month and 80 days postpartum but not at 165 days postpartum.

The paper identifies extensive gene regulatory rewiring between in vitro-produced conceptuses and endometrium during implantation, contributing to pregnancy loss in cattle.

The paper identifies a frameshift mutation in IFT80 causing embryonic lethality in Holstein cattle and validates it using CRISPR-Cas9 knockout embryos.