Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage
Alessandro Brombin, Stephanie MacMaster, Jana Trávníčková, Cameron Wyatt, Hannah Brunsdon, Emma Ramsey, Hong Nhung Vu, Eirı́kur Steingrı́msson, Colin Kenny, Tamir Chandra, E. Elizabeth Patton
The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.
bioRxiv · Apr 12, 2026 · PreprintDevelopmental Biology