Discovery of a hydrolysis operon in Lachnospiraceae provides a genetic basis to understanding castalagin metabolism by the human microbiome in a clinical study.
Arianna Giurleo, Reilly Pidgeon, Emmanuel Gonzalez, Emma Thauvin, Lharbi Dridi, Corinne F. Maurice, André Marette, Bastien Castagner
The paper identifies a hydrolysis operon in Lachnospiraceae that enables castalagin metabolism to urolithins and flavogallonic acid in the human gut microbiome using multi-omics analysis of fecal samples from a clinical trial.
bioRxiv · Oct 6, 2026 · PreprintMicrobiology