Bastien Castagner

Discovery of a hydrolysis operon in Lachnospiraceae provides a genetic basis to understanding castalagin metabolism by the human microbiome in a clinical study.

The paper identifies a hydrolysis operon in Lachnospiraceae that enables castalagin metabolism to urolithins and flavogallonic acid in the human gut microbiome using multi-omics analysis of fecal samples from a clinical trial.

Mistrafficking of KCC2 promotes hyperexcitability in hippocampal circuitry in a murine model of Christianson Syndrome

The paper identifies endosomal dysfunction in a murine model of Christianson Syndrome as a cause of inhibitory circuit hyperexcitability through KCC2 mistrafficking.

The Microbiota Dictates Vendor-Derived Differences in a Murine Clostridioides difficile Infection Model

This study shows that differences in gut microbiota between two mouse vendors affect susceptibility to C. difficile infection, and cohousing can transfer resistance.

Early life γδT cell activation enforces intestinal barrier integrity during intergenerational C. difficile colonization

The paper identifies a microbiota-dependent type 3 immune response in mice during weaning that involves γδ T cells, which limit C. difficile growth and maintain intestinal barrier integrity.

The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species

This study identifies a novel urolithin dehydroxylase operon in Enterocloster species and shows its regulation by 9-hydroxy urolithins.

The dietary ellagitannin metabolite urolithin A is produced by a molybdenum-dependent dehydroxylase encoded by prevalent human gut Enterocloster spp.

The paper identifies Enterocloster spp. and the ucd operon as key producers of urolithin A from dietary ellagitannins using multi-omics approaches.

Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample

The paper identifies novel Blautia species as fructo-oligosaccharide (FOS) consumers using pulse metatranscriptomics in a human stool sample.

Clostridioides difficile Toxins Unhinged: Allosterically Switchable Network Orients β-flap

The paper reveals an allosteric mechanism in Clostridioides difficile toxins using MD simulations and mutagenesis, showing a switchable interaction network that drives conformational changes.