Leveraging AI and structural proteomics for rational design of a KAT6A degrader
Gali Arad, Nitzan Simchi, Sagie Brodsky, Alon Shtrikman, Yonatan Kedem, Iris Alchanati, Galina Otonin, Anjana Shenoy, Dimitri Kovalerchik, Michal Ran Shchory, Yaron Ben Shoshan-Galeczki, Noam Cohen, Katharina Lange, Eran Seger, Kirill Pevzner
The paper develops an AI-driven platform for rational PROTAC design, enabling the optimization of a KAT6A degrader with potent in vivo activity.
bioRxiv · May 28, 2026 · PreprintBioinformatics