Tamar Geiger

Vesicular pseudopodia define the fusion site on large secretory vesicles of the Drosophila salivary glands

The paper identifies vesicular pseudopodia as fusion sites on large secretory vesicles in Drosophila salivary glands and shows their coordination with apical domains for efficient exocytosis.

High throughput single-cell proteomics of in-vivo cells

The paper develops a high-throughput single-cell proteomics pipeline for tumor analysis, identifying over 1,800 proteins per cell in murine lung metastasis models.

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

A Novel Algorithm for the Harmonization of Pan-cancer Proteomics

This paper introduces a novel framework for harmonizing pan-cancer proteomics data, demonstrating its effectiveness in improving dataset integration and revealing prognostic markers.

Distinct extracellular-matrix remodeling events precede symptoms of inflammation

The paper identifies a pre-symptomatic extracellular-matrix signature in colitis models and validates it in human subjects, showing its mediation by neutrophils and monocytes.

Spatio-temporal Proteomic Analysis of Stress Granule disassembly using APEX Reveals Regulation by SUMOylation and links to ALS pathogenesis

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

Systematic detection of amino acid substitutions in proteome reveals a mechanistic basis of ribosome errors

The paper systematically detects amino acid substitutions in proteomes using mass spectrometry data and reveals that translation errors are primarily caused by codon-anticodon mispairing, with patterns influenced by ribosome velocity and evolutionary constraints.