Author

Sagie Brodsky

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Systems Biology· 3 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Naama BarkaiiD· 4 shared Gili Valinsky· 2 shared Michal Chapal· 2 shared Miri CarmiiD· 2 shared Tamar Jana· 2 shared Vladimir MindeliD· 2 shared Wajd Manadre· 2 shared Alon ShtrikmaniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersSystems Biology

Naama BarkaiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Leveraging AI and structural proteomics for rational design of a KAT6A degrader

Gali Arad, Nitzan Simchi, Sagie Brodsky, Alon Shtrikman, Yonatan Kedem, Iris Alchanati, Galina Otonin, Anjana Shenoy, Dimitri Kovalerchik, Michal Ran Shchory, Yaron Ben Shoshan-Galeczki, Noam Cohen, Katharina Lange, Eran Seger, Kirill Pevzner

The paper develops an AI-driven platform for rational PROTAC design, enabling the optimization of a KAT6A degrader with potent in vivo activity.

bioRxiv · May 28, 2026 · PreprintBioinformatics

Protein massively parallel binding assay reveals transcription factor binding determinants

Offir Lupo, Sagie Brodsky, Tamar Jana, Wajd Manadre, Gili Valinsky, Yoav Navon, Vladimir Mindel, Naama Barkai

The paper introduces pMPBA, a method to analyze peptide-DNA binding in yeast, revealing determinants both within and outside predicted DNA binding domains.

bioRxiv · Mar 5, 2025 · PreprintGenomics

Massively Parallel Binding Assay (MPBA) reveals limited transcription factor binding cooperativity, challenging models of specificity

Tamar Jana, Sagie Brodsky, Wajd Manadre, Matan Vidavski, Gili Valinsky, Vladimir Mindel, Guy Ilan, Miri Carmi, Felix Jonas, Naama Barkai

The paper challenges the model of transcription factor binding cooperativity by showing limited effects of motif combinatorics in yeast using a novel massively parallel binding assay.

Nucleic Acids Research · Oct 16, 2024Peer-reviewedSystems Biology

Transcription-factor binding to replicated DNA

Raz Bar‐Ziv, Sagie Brodsky, Michal Chapal, Naama Barkai

The paper shows that transcription factor binding to replicated DNA increases with DNA dosage, while RNA polymerase II binding remains stable during S phase in budding yeast.

Cell Reports · Mar 1, 2020Peer-reviewedSystems Biology

Resolving noise-control conflict by gene duplication

Michal Chapal, Sefi Mintzer, Sagie Brodsky, Miri Carmi, Naama Barkai

The paper shows that gene duplication in budding yeast allows stress regulators to function cooperatively, reducing noise while maintaining environmental responsiveness.

PLoS Biology · Nov 22, 2019Peer-reviewedSystems Biology