Generating snoRNA-guided Programmable 2'O-methylation
Justin Zhao, Eric Cockman, Xinhe Yin, Yvonne L. Chao, Chad Victor Pecot, Christopher L. Holley
This paper introduces an RNase H-based assay to validate 2'O-methylation sites and demonstrates synthetic snoRNAs can guide Nm modifications in mRNA.
bioRxiv · Nov 18, 2024 · PreprintMolecular Biology