Chad Victor Pecot

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)

This study identifies that macrophage-secreted pyrimidine metabolites confer chemotherapy resistance in AML by inhibiting drug activation, and shows that targeting macrophage metabolism can restore drug sensitivity.

Alcohol use reduces the efficacy of anti-PD1 immunotherapy by disrupting anti-tumor immunity

This study shows alcohol use reduces anti-PD1 immunotherapy efficacy in cancer patients and mouse models by impairing T cell function and anti-tumor immunity.

Isolation Methods of Tumor Endothelial Cells Impact AngiomiR Profiles

This study shows that different methods of isolating tumor endothelial cells affect the expression of angiomiRs, with in vivo methods yielding more reliable results than in vitro methods.

Generating snoRNA-guided Programmable 2'O-methylation

This paper introduces an RNase H-based assay to validate 2'O-methylation sites and demonstrates synthetic snoRNAs can guide Nm modifications in mRNA.

An Integrated Model for Predicting KRAS Dependency

The paper develops a model to predict KRAS dependency using molecular profiles from cell lines, achieving high accuracy in validation and external datasets.