A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants
Grigorios Papageorgiou, El Chérif Ibrahim, Victor Gorgievski, Gabriella Maxson, Evelyn Lozano, Eric Gordon, Antoine Lefrere A, Marie-Julie Toupet, Philippe Courtet, Raoul Belzeaux-R, Jane Allyson Foster, Thomas Carmody, Roy H. Perlis, Madhukar H. Trivedi, Eleni T. Tzavara, Nikolaos Mellios
This paper identifies a brain-enriched circRNA in blood that predicts response to SSRI antidepressants and is regulated by 5-HT2A and BDNF signaling.
Molecular Psychiatry · Feb 17, 2026Peer-reviewedNeuroscience