Philippe Courtet

A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants

This paper identifies a brain-enriched circRNA in blood that predicts response to SSRI antidepressants and is regulated by 5-HT2A and BDNF signaling.

Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

This study investigates associations between mitochondrial metabolites and metabolic syndrome in bipolar disorder, finding significant links between lactate levels and metabolic syndrome markers, while cell-free mitochondrial DNA showed no association.

Evaluating and mitigating clinical samples matrix effects on TX-TL cell-free performance

The paper evaluates matrix effects on cell-free biosensor performance in clinical samples and introduces a method to mitigate these effects using a modified RNase inhibitor.

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

Plug-and-Play Metabolic Transducers Expand the Chemical Detection Space of Cell-Free Biosensors

This paper introduces hybrid cell-free biosensors that expand the range of detectable chemicals by combining synthetic metabolic cascades with transcription factor-based networks.

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.