Immunomodulatory Role of the Stem Cell Circadian Clock in Muscle Repair
Pei Zhu, Eric M. Pfrender, Adam W. T. Steffeck, Colleen R. Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R. Gupta, Ariana Kupai, Amber R. Willbanks, Richard L. Lieber, Ishan Roy, Navdeep S. Chandel, Clara Bien Peek
This study shows that the circadian clock in muscle stem cells modulates immune responses and inflammation during muscle regeneration through NAD+ metabolism and CCL2 signaling.
Science Advances · Mar 5, 2025Peer-reviewedDevelopmental Biology