Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene
Brynna Webb, Hieu Trinh, Emily A. Breach, Kendall M. Foote, Erica Binelli, Geoffrey T. Swanson
This study creates mouse models of GRIK2 variants causing neurodevelopmental disorders and finds they exhibit behavioral and seizure-related impairments similar to humans.
bioRxiv · Aug 8, 2025 · PreprintNeuroscience