Geoffrey T. Swanson

Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene

This study creates mouse models of GRIK2 variants causing neurodevelopmental disorders and finds they exhibit behavioral and seizure-related impairments similar to humans.

A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model

This study investigates altered excitability in the bed nucleus of the stria terminalis (BNST) and its projections to the parabrachial nucleus in a Dravet syndrome mouse model, linking these changes to potential comorbidities like respiratory dysfunction.