Cancer BiologybioRxiv
Single-chromosome aneuploidy commonly functions as a tumor suppressor
Jason Meyer Sheltzer, Julie H. Ko, Nicole C. Habibe Burgos…·Angelika Amon
This study shows that single-chromosome aneuploidy often suppresses tumorigenesis, as aneuploid cell lines grew poorly compared to euploid ones, but some evolved to overcome this by acquiring additional karyotype changes.
DOI 10.1016/j.ccell.2016.12.004