Non-Physiological Potassium Concentrations in Commercial Culture Media Trigger Acute Epileptiform Activity in Human iPSC-Derived Neurons
Tim Lyckenvik, Júlia Izsák, Erik Arthursson, My Forsberg, Kalle Johansson, Henrik Zetterberg, Markus Axelsson, Pontus Wasling, Eric Hanse, Stephan Theiss, Sebastian Illes
This study shows that common cell culture media cause non-physiological epileptiform activity in human iPSC-derived neurons due to high potassium concentrations, unlike cerebrospinal fluid.
bioRxiv · May 31, 2025 · PreprintNeuroscience