Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration
Gregory R. Keele, Yue Dou, Seth P. Kodikara, Erin D. Jeffery, Dina L. Bai, Erik Hultenius, Zichen Gao, João A. Paulo, Steven P. Gygi, Xiao Yan Tian, Tian Zhang
This study uses Orbitrap Astral mass spectrometry with TMT to analyze proteomic changes in mouse brain and kidney tissues across age and sex, revealing tissue-specific and non-linear age-related protein dynamics.
Nature Communications · May 22, 2025Peer-reviewedSystems Biology