Steven P. Gygi

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.

The paper shows that ribosome remodeling enables enhanced viral protein synthesis during infection and cellular stress by altering ribosome composition and structure.

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

Traffickome infers directed membrane trafficking between cellular compartments from proteomic data, achieving high accuracy in predicting trafficking transitions.

This study identifies how calcineurin (CN) is recruited to the cytokinetic ring in fission yeast and shows that Rcn1 inhibits CN to regulate cytokinesis.

The paper identifies activation and inactivation pathways of Mga2, a p53-like transcription factor in yeast, showing its role in lipid homeostasis through regulation of Ole1 expression.

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

The paper shows that amino acid stress shifts c-myc translation from AUG-initiated to CUG-initiated isoforms via ribosome stalling and queue formation.

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

The paper identifies lineage-specifying transcription factors that directly control metabolism to ensure cell function.

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

This study identifies activity-dependent lipid droplet formation and lipophagy as critical regulators of synaptic integrity and neuronal function using a novel genetic reporter in cultured neurons and mouse motor cortex.

The paper identifies a feedback mechanism where G1-cyclin-Cdc28Cdk1 corrects polarity errors during cell cycle progression in budding yeast, but can lead to multinucleate cells if defects are irreparable.

The paper identifies that X chromosome dosage influences aneuploidy development in mouse embryonic stem cells, with XO and XY lines showing higher aneuploidy rates than XX lines.

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study compares cysteine ligandability in live cells and native lysates, identifying factors like accessibility, abundance, and relocalization, and shows THZ1 induces chromatin binding.

The paper identifies CDK/mTOR-dependent phosphorylation of UBE2H as a regulator of CTLH E3 ligase activity, showing how it controls ubiquitylation and substrate degradation.

This paper introduces a high-resolution multi-pass Astral analyzer mode for TMT proteomics, enabling 35-plex quantification with improved depth and precision.

The paper identifies SWIFT, a SWI/SNF subunit domain that mediates transcription factor interactions, showing its role in chromatin targeting and cancer cell proliferation.

This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.

This study identifies shifted mSWI/SNF subcomplex stoichiometry in DDEC/UEC cancers and shows that SMARCA4/2 inhibitors reduce tumor growth and synergize with chemotherapy.

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

This study identifies MECOM's role in blocking differentiation via CEBPA repression, showing that targeting this regulatory element can promote differentiation and reduce leukemia burden in AMLs.

This study shows that increasing JAG1 expression in dystrophin-deficient mice improves muscle size, strength, and myofiber number.

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

GoDig-LiF enables targeted proteomics without data libraries by using predicted spectra and retention times, applied to quantify mutated proteins in cancer cell lines.

GoDig 2.0 improves targeted proteomics by increasing multiplexing, efficiency, and target coverage, enabling analysis of post-translational modifications and compound-protein interactions.