Yue Dou

CysLENS identifies cysteine ligandability by integrating chemoproteomic data with protein language models to prioritize stereoselective interactions.

The paper identifies Hsp90 inhibitors as MHC-I inducers and develops novel compounds using click chemistry to enhance T cell activation and reduce toxicity.

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

ISDia tracks protein synthesis and clearance during ER stress, revealing PERK-dependent and independent regulatory mechanisms across subcellular compartments.

This study uses Orbitrap Astral mass spectrometry with TMT to analyze proteomic changes in mouse brain and kidney tissues across age and sex, revealing tissue-specific and non-linear age-related protein dynamics.