Imprinted antibody lineages can persist for half a century and dominate cross-neutralizing recall responses to poliovirus
Gregory C. Ippolito, Jonathan R. McDaniel, Brian C. Schanen, Diana V. Kouiavskaia, Daniel R. Boutz, Hidetaka Tanno, Megan M. Wirth, Erik Johnson, John Blazeck, Daechan Park, Bing Tan, Ellen M. Murrin, Konstantin Chumakov, Donald R. Drake, George Georgiou, Jason J. Lavinder
This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.
bioRxiv · Dec 25, 2025 · PreprintImmunology