Gregory C. Ippolito

Enhanced Pathogenicity and Contact Transmissibility of Human-origin Avian Influenza H5N1 Clade 2.3.4.4b Genotype B3.13 Compared to D1.1 in Ferrets

This study compares the pathogenicity and transmissibility of two H5N1 genotypes in ferrets, finding B3.13 is more pathogenic and transmissible than D1.1, while D1.1 acquires adaptive mutations rapidly.

Broad Sarbecovirus Neutralization by an S2-Directed Plasma Antibody Defines a New Site of Vulnerability in SARS-like Viruses

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

Synergistic non-neutralizing plasma antibodies to PfRH5 drive potent malaria parasite growth inhibition

The paper identifies synergistic non-neutralizing antibodies against PfRH5 that enhance malaria parasite growth inhibition when combined with neutralizing antibodies.

Imprinted antibody lineages can persist for half a century and dominate cross-neutralizing recall responses to poliovirus

This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.

A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants

This study shows that a combination of antibodies targeting both the SARS-CoV-2 spike protein's receptor binding domain (RBD) and stem helix (SH) domains prevents the emergence of viral escape mutants.

Profile of the B cell receptor repertoire and antibody responses upon 17DD-YF vaccine boosting

This study examines the B cell receptor repertoire and antibody responses after 17DD-YF vaccine boosting, finding a transient antibody response with limited neutralization capacity and rapid clonal expansion of IgA and IgG isotypes.

Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine

This study shows that the R21/Matrix-M malaria vaccine induces specific IgG antibodies targeting multiple CSP epitopes, contributing to its efficacy against P. falciparum malaria.

Lymphoid origin of a lineage of intrinsically activated plasmacytoid dendritic cell in mice and humans

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality

The paper identifies SARS-CoV-2 neutralizing antibodies from convalescent patients and describes a novel quaternary binding mechanism using high-throughput methods.