4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity
Jephte Yao Akakpo, Erika Abbott, Benjamin Leeland Woolbright, Anup Ramachandran, Rick G. Schnellmann, Darren P. Wallace, John Arthur Taylor
This study shows that inhibiting CYP2E1 with 4MP protects kidneys from cisplatin toxicity but does not affect cisplatin's anti-cancer effects in bladder cancer cells.
Toxicological Sciences · Apr 30, 2025Peer-reviewedPharmacology & Toxicology