Author

Jephte Yao Akakpo

University of Kansas Medical CenterORCID 0000-0001-5324-1164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Anup RamachandraniD· 1 shared Benjamin Leeland WoolbrightiD· 1 shared Colin S. McCoiniD· 1 shared Darren P. WallaceiD· 1 shared Elizabeth JonesiD· 1 shared Erika Abbott· 1 shared Forkan AhamediD· 1 shared Hartmut JaeschkeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

Anup RamachandranORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyToxicologyPeer-reviewedApr 30, 2026

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

Natalie Eppler, Elizabeth Jones, Forkan Ahamed…·Yuxia Zhang

This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.

1 citation

mousebulk RNA-seq

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Pharmacology & ToxicologyToxicological SciencesPeer-reviewedApr 30, 2025

4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity

Jephte Yao Akakpo, Erika Abbott, Benjamin Leeland Woolbright…·John Arthur Taylor

This study shows that inhibiting CYP2E1 with 4MP protects kidneys from cisplatin toxicity but does not affect cisplatin's anti-cancer effects in bladder cancer cells.

7 citations

mousehuman

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