Highly efficient XIST reactivation in female hPSC by transient dual inhibition of TP53 and DNA methylation during Cas9 mediated genome editing
Nami Motosugi, Keita Hasegawa, Natsumi Kurosaki, Erika Kawaguchi, Kenji Izumi, Yumi Iida, Misaki Higashiseto, Keiko Yokoyama, Ayumi Sasaki, Kazuhiko Nakabayashi, Atsushi Fukuda
The paper develops a method to efficiently reactivate XIST in female hPSCs by inhibiting TP53 and DNA methylation during Cas9-mediated genome editing.
Stem Cell Research & Therapy · Jul 18, 2025Peer-reviewedCell Biology