Cell BiologybioRxivPreprint
Upregulation of the lncRNA XACT sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cells
DOI 10.1101/2025.10.02.679492
Author
Atsushi Fukuda
Tokai UniversityORCID 0000-0001-7320-7457Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2025 · peak 2/yrCo-Author Collaboration Network
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Recent·Most cited
- Cell BiologyStem Cell Research & TherapyPeer-reviewed
Highly efficient XIST reactivation in female hPSC by transient dual inhibition of TP53 and DNA methylation during Cas9 mediated genome editing
Nami Motosugi, Keita Hasegawa, Natsumi Kurosaki…·Atsushi Fukuda
The paper develops a method to efficiently reactivate XIST in female hPSCs by inhibiting TP53 and DNA methylation during Cas9-mediated genome editing.
- NeurosciencebioRxivPreprint
Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons
Jin Hao, Michael F. Wells, Gengle Niu…·Kevin C. Eggan
This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.
17 citations