Glycosylation of Plasmodium falciparum TRAP supports sporozoite motility and invasion.
Priya Gupta, Vladimir I. Vigdorovich, Nastaran Rezakhani, Lucia Pazzagli, Hardik Patel, Gigliola Zanghì, Mohd Kamil, Alexander Watson, Nelly M. Camargo, Erin Knutson, Robert L. Moritz, Stefan H. I. Kappe, D. Noah Sather, Ashley M. Vaughan, Kristian E. Swearingen
This study shows that glycosylation of PfTRAP's TSR domain is essential for sporozoite motility and invasion, as glyco-null mutants exhibit severe fitness defects.
bioRxiv · Jun 26, 2025 · PreprintCell Biology