Ashley M. Vaughan

The paper investigates the bimodal piperaquine response in Plasmodium falciparum by analyzing metabolic, transcriptional, and molecular dynamics data to identify the role of plasmepsin II/III copy number and pfcrt mutations.

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

The paper investigates the fitness consequences of selfing and outcrossing in malaria parasites using fluorescent-labelled clones and finds an outcrossing advantage linked to faster sporozoite maturation and increased recombination.

This study shows that glycosylation of PfTRAP's TSR domain is essential for sporozoite motility and invasion, as glyco-null mutants exhibit severe fitness defects.

This paper generates a transgenic P. cynomolgi parasite expressing P. vivax CSP to study anti-CSP interventions against relapsing malaria.

The paper isolates a human monoclonal antibody that targets Plasmodium vivax AMA1, blocking both pre-erythrocytic and blood stage infections.

MalKinID identifies malaria parasite genealogical relationships using IBD proportions and segment distributions, showing high accuracy in outcrossed importations but reduced performance in inbreeding scenarios.

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

The paper uses bulk segregant analysis to identify genetic loci affecting malaria parasite growth in different media, finding EBA-140 as a key gene involved in media-dependent fitness.

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.