Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea
Ippei Kishimoto, Abel P. David, Kevin P. Rose, Balasubramanian Narasimhan, Bradley Efron, Sara E. Billings, Erin L. Su, Wuxing Dong, Taha Adnan Jan, Ronna P. Hertzano, Alan Gi-Lun Cheng
The paper investigates the role of Wnt signaling in cochlear development, showing that Wnt proteins from both epithelial and mesenchymal compartments guide cochlear outgrowth and hair cell polarization, with redundancy across compartments.
Nature Communications · Sep 16, 2026Peer-reviewedDevelopmental Biology