Ronna P. Hertzano

Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea

The paper investigates the role of Wnt signaling in cochlear development, showing that Wnt proteins from both epithelial and mesenchymal compartments guide cochlear outgrowth and hair cell polarization, with redundancy across compartments.

A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical Development

The paper compiles a large transcriptomic dataset of neocortical development and uses joint matrix decomposition to identify conserved transcriptome dynamics across mammals and developmental stages.

Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas.

The paper identifies variable merlin inactivation in schwannomas and shows TEAD1 inhibition can reverse hippo signaling and suppress tumor growth.

Cochlear organoids reveal epigenetic and transcriptional programs of postnatal hair cell differentiation from supporting cells

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain

The paper describes the Neuroscience Multi-Omic Archive, a repository for single-cell transcriptomic and epigenomic data from mammalian brains, providing tools for data access and analysis.

The BRAIN Initiative Cell Census Data Ecosystem: A User's Guide

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

A multimodal cell census and atlas of the mammalian primary motor cortex

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types

The paper creates a comprehensive atlas of mouse primary motor cortex cell types using integrated transcriptomic and epigenomic data from over 600,000 samples.

gEAR: gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

gEAR provides a community-driven portal for multi-omic data visualization, analysis, and sharing across species and data types.

Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty

The paper identifies 31 new genomic risk loci for hearing difficulty using GWAS and multi-omic analysis, highlighting gene regulation in cochlear cells.

Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1

The paper identifies genetic causes of inherited hearing loss in the Israeli Jewish population, finding a novel deafness gene ATOH1 and demonstrating the effectiveness of targeted genomic sequencing.

Individual differences in stereotypy and neuron subtype translatome with TrkB deletion

The paper investigates how TrkB deletion in D1-MSNs leads to stereotypy behavior and identifies molecular and morphological changes in these neurons.

Genomic knockout of alms1 in zebrafish recapitulates Alstrom syndrome and provides insight into metabolic phenotypes

This paper generates a zebrafish model of Alstrom syndrome by knocking out alms1, revealing metabolic defects and beta-cell dysfunction linked to obesity and diabetes.