Alan Gi-Lun Cheng

Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo

Single-cell profiling of mouse greater epithelial ridge (GER) organoids points to galectin-1 and Myc as drivers of cochlear progenitor expansion. Myc overexpression also yields organoids from post-hearing-onset cochlear epithelium.

Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea

The paper investigates the role of Wnt signaling in cochlear development, showing that Wnt proteins from both epithelial and mesenchymal compartments guide cochlear outgrowth and hair cell polarization, with redundancy across compartments.

Graded Hair Cell Ablation Reveals Functional Redundancy in the Mature Mouse Vestibular System

This study shows that the adult mouse vestibular system maintains functional responses despite significant hair cell loss, with different levels of redundancy in macula and crista ampullaris.

Benchmarking Cell Type and Gene Set Annotation by Large Language Models with AnnDictionary

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

Single-cell, spatial, and fate-mapping analyses uncover niche dependent diversity of cochlear myeloid cells.

This study identifies five myeloid cell types in the mouse cochlea using single-cell transcriptomics, fate mapping, and parabiosis, revealing their spatial distribution, ontogeny, and functional diversity.