CRISPRa-mediated activation of Tfeb in a fibril-induced alpha-synuclein aggregation model
Elin Arvidsson, Elsa Pi Börjesson, Ermelinda Sabarese, Luís Quintino, Cecilia Lundberg
The paper uses CRISPRa to activate Tfeb in a rat model of alpha-synuclein aggregation but finds limited protein expression and no additive effects with media treatments.
bioRxiv · Oct 19, 2026 · PreprintMolecular Biology