Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure
Eric Latorre Crespo, Neil Robertson, Esra Gozde Kosebent, Louise MacGillivray, Lee Murphy, Md Mesbah Uddin, Eric A. Whitsel, Michael C. Honigberg, Alexander G. Bick, Alex P. Reiner, Valeria Orrù, Michele Marongiu, Francesco Cucca, Edoardo Fiorillo, Ian J. Deary, , Kristina Kirschner
The paper investigates how mutation timing, fitness, and clonal structure influence the clinical progression of clonal hematopoiesis using longitudinal cohort data.
bioRxiv · Feb 28, 2025 · PreprintGenetics